We are interested in fundamental questions of human reproduction in health and disease (infertility). Our models include human testicular and ovarian cells. We use various cellular and molecular techniques and cooperate with groups at the BMC, the Gene Center and with national and international partners.
© J. Greune / LMU
+49 89 2180 75859
mayerhofer@bmc.med.lmu.de
Research Topics
https://orcid.org/0000-0002-9388-4639
Top 5 Publications
Mayerhofer A, Dissen GA, Costa ME, Ojeda SR. A role for neurotransmitters in early follicular development: induction of functional follicle-stimulating hormone receptors in newly formed follicles of the rat ovary. Endocrinology. 1997 Aug;138(8):3320-9.
Mayerhofer A, Smith GD, Danilchik M, Levine JE, Wolf DP, Dissen GA, Ojeda SR. Oocytes are a source of catecholamines in the primate ovary: evidence for a cell-cell regulatory loop. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10990-5.
Pfeifer A, Klatt P, Massberg S, Ny L, Sausbier M, Hirneiss C, Wang GX, Korth M, Aszódi A, Andersson KE, Krombach F, Mayerhofer A, Ruth P, Fässler R, Hofmann F. Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J. 1998 Jun 1;17(11):3045-51.
Frungieri MB, Weidinger S, Meineke V, Köhn FM, Mayerhofer A. Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma: Possible relevance to human fibrotic disorders. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15072-7.
Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR, Guo J. Single-cell analysis of human testis aging and correlation with elevated body mass index. Dev Cell. 2022 May 9;57(9):1160-1176.e5.
Our research focuses on the human gonads. We use mainly cellular models to better understand the
1. Function and regulation of testicular peritubular cells
2. Function and regulation of ovarian granulosa cells and ovarian granulosa cell tumors
| Name | Title | Telephone | Position | |
|---|---|---|---|---|
| Eubler, Katja | Dr. | katja.eubler@bmc.med.lmu.de | +49 89 2180 75866 | Postdoc |
| Herrmann, Carola | carola.herrmann@bmc.med.lmu.de | +49 89 2180 75866 | Technician | |
| Jiang, Yuhao | Yuhao.Jiang@bmc.med.lmu.de | +49 89 2180 75866 | Doctoral researcher | |
| Liebich, Annika | Dr. | annika.liebich@bmc.med.lmu.de | +49 89 2180 75861 | Postdoc |
| Schneider, Michaela | michaela.schneider@bmc.med.lmu.de | +49 89 2180 75861 | Doctoral researcher | |
| Scholz, Lina | lina.scholz@bmc.med.lmu.de | +49 89 2180 75861 | Doctoral researcher | |
| Welter, Harald | Dr. | welter@bmc.med.lmu.de | +49 89 2180 75836 | Postdoc |
© J. Greune / LMU
Actin cytoskeleton dynamic
+49 89 2180 75873
amueller@bmc.med.lmu.de
Research Topics
Publications: https://orcid.org/0000-0003-1163-9232
The actin cytoskeleton of non-muscle cells is essential for cellular structure, and the dynamic regulation of actin is a prerequisite for motility. To explore the principles and mechanisms of actin cytoskeletal dynamics we are using mammalian cell lines and the model organism Dictyostelium discoideum. We employ methods from cell biology and biochemistry in combination with in vivo imaging to elucidate the molecular basis of fundamental actin-based processes that are crucial for cell motility, subcellular organization, and cellular integrity.
